Glycoprotein Ia C807T gene polymorphism and increased risk of recurrent acute coronary syndromes: a five year follow up.

D espite aggressive control of modifiable risk factors, recurrent acute coronary syndromes are still common, and the underlying mechanisms largely elusive. Glycoprotein (Gp) Ia/IIa is one of several collagen receptors involved in platelet adhesion. A C807T gene variant of GpIa is related to Gp Ia/IIa receptor density on the platelet surface, with the density proportionate to the number of T alleles. Previous case-control studies in white subjects have associated this variant with acute ischaemic heart disease. As it is not known whether the 807T allele may also predict recurrent acute coronary syndromes, this was investigated in 117 survivors of a first acute coronary event; patients were followed for up to five years.